Research

 
 

The focus of our research is the development of selective molecular probes to enable investigation of certain biological systems. This aim leads us to develop novel synthetic organic chemistry. Our research can be grouped into three main areas, which are described in more detail below:

 

Research Interests

Hydantoins are an important structural motif found in many natural products and pharmaceutically significant molecules. We are developing new synthetic methods to obtain these important molecules. Read more...

Chemical BiologyInositol_signalling.html
PhotoChemical BiologyCaged_compounds.html
Synthetic ChemistryHydantoin_synthesis.html

Inositol polyphosphates are involved in many important cellular processes. The synthesis of inositol polyphosphate derivatives allows us to selectively interact with the protein targets of these molecules and hence gain an understanding of their cellular function. Read more...

Synthesis of InsP3R ligandsInositol_signalling.html

Photolabile protecting groups can be used to mask biologically active compounds, which can then be released within a biological system by irradiation with light. This methodology provides spatial and temporal control over the release of these compounds and hence the activation of their cellular targets.  Read more...